Obsessive-compulsive symptoms in clozapine-treated schizophrenic patients

Aygun Ertugrul; A Elif Anil Yagcioglu; Nurhayat Eni; Kâzim M Yazici

doi:10.1111/j.1440-1819.2005.01362.x

Obsessive-compulsive symptoms in clozapine-treated schizophrenic patients

Psychiatry Clin Neurosci. 2005 Apr;59(2):219-22. doi: 10.1111/j.1440-1819.2005.01362.x.

Authors

Aygun Ertugrul¹, A Elif Anil Yagcioglu, Nurhayat Eni, Kâzim M Yazici

Affiliation

¹ Hacettepe University Faculty of Medicine, Department of Psychiatry, Ankara 06100, Turkey. aertugru@hacettepe.edu.tr

PMID: 15823172
DOI: 10.1111/j.1440-1819.2005.01362.x

Abstract

The aim of the present study was to assess the occurrence of obsessive-compulsive symptoms (OCS) in schizophrenic patients treated with clozapine, and to examine the relationship between OCS and other clinical variables. The results support earlier findings which suggest that clozapine produces or unmasks OCS. In addition, the severity of OCS was not related to other dimensions of psychopathology, severity of illness, clinical improvement or dose and duration of clozapine treatment.

MeSH terms

Adult
Antipsychotic Agents / administration & dosage
Antipsychotic Agents / adverse effects
Antipsychotic Agents / therapeutic use*
Clozapine / administration & dosage
Clozapine / adverse effects
Clozapine / therapeutic use*
Female
Humans
Male
Obsessive-Compulsive Disorder / complications*
Obsessive-Compulsive Disorder / drug therapy*
Obsessive-Compulsive Disorder / psychology
Psychiatric Status Rating Scales
Schizophrenia / complications*
Schizophrenia / drug therapy*
Schizophrenic Psychology*
Selective Serotonin Reuptake Inhibitors / therapeutic use

Substances

Antipsychotic Agents
Serotonin Uptake Inhibitors
Clozapine