Positive Kveim test in patients with coexisting sarcoidosis and human immunodeficiency virus infection

Chest. 1992 May;101(5):1454-6. doi: 10.1378/chest.101.5.1454.


We present two cases of sarcoidosis complicated by HIV infection. Each case had a different level of sarcoidosis activity and coexisted with either an AIDS-related infection or a HIV-positive state. Manifestations of sarcoidosis were not apparent in the patient with the AIDS-defining opportunistic infection, but were active in the patient with asymptomatic HIV infection. Both patients had granulomatous reactions to Kveim antigen, and one had such a reaction following an AIDS-defining infection. These findings suggest that non-T-cell mechanisms may be involved in granuloma formation in sarcoidosis.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Female
  • HIV Infections / complications*
  • Humans
  • Kveim Test*
  • Sarcoidosis / complications
  • Sarcoidosis / diagnosis*
  • Sarcoidosis / pathology
  • Skin / pathology