Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 11 (3), 151-5

Dyskinesias Predict the Onset of Motor Response Fluctuations in Patients With Parkinson's Disease on L-dopa Monotherapy

Affiliations

Dyskinesias Predict the Onset of Motor Response Fluctuations in Patients With Parkinson's Disease on L-dopa Monotherapy

L Mazzella et al. Parkinsonism Relat Disord.

Abstract

The aim of the study was to investigate the relationship between dyskinesias and motor fluctuations in patients with Parkinson's disease on l-dopa monotherapy. We identified 116 patients on l-dopa monotherapy treated between 1965 and 1992 and followed until death. Dyskinesias occurred in 102 patients. Of these, 48 only developed dyskinesias while 54 had both dyskinesias and motor fluctuations. Among patients with both complications, 49 developed dyskinesias before fluctuations, and only five had dyskinesias after the onset of fluctuations. Our findings suggest that dyskinesias predict the onset of motor fluctuations, and may share a common pathophysiological mechanism.

Similar articles

See all similar articles

Cited by 2 articles

LinkOut - more resources

Feedback