BRCA2: breaks, mistakes and failed separations

Trends Mol Med. 2005 Apr;11(4):145-8. doi: 10.1016/j.molmed.2005.02.003.


BRCA2 was identified in 1995, one year after BRCA1. In terms of knowledge of the function of its product, BRCA2 has remained the less well-characterised gene. Both BRCA1 and BRCA2 are closely implicated in the repair of double-strand breaks in DNA by homologous recombination, but beyond that a function for BRCA2 has been hard to discern. A recent study has extended the function of BRCA2 to the regulation of cell cleavage and separation. Other groups have also shown how BRCA2, RAD51 and DSS1 co-exist in a ménage à trois and how the disruption of any one of the three cohabitants can have disastrous consequences for the cell.

Publication types

  • Review

MeSH terms

  • BRCA1 Protein / genetics
  • BRCA2 Protein / genetics
  • Cytokinesis / genetics
  • Genes, BRCA2*
  • Humans
  • Mutation
  • Neoplasms / genetics*
  • Phenotype


  • BRCA1 Protein
  • BRCA2 Protein