The many faces of celiac disease: clinical presentation of celiac disease in the adult population

Gastroenterology. 2005 Apr;128(4 Suppl 1):S74-8. doi: 10.1053/j.gastro.2005.02.016.


The major modes of presentation of patients with celiac disease are the classic diarrhea-predominant form and silent celiac disease. Those with silent celiac disease lack diarrhea, although they may present with manifestations of celiac disease that include an irritable bowel syndrome, anemia, osteoporosis, neurologic diseases, or malignancy. A significant proportion of patients are diagnosed through screening at-risk groups including relatives of patients and insulin-dependant diabetics. Nondiarrheal presentations now are seen more commonly than those with diarrhea. Patients with celiac disease have a greater burden of disease than the general population because of autoimmune diseases and malignancies. There is a need for screening studies of patients with conditions associated with celiac disease to determine whether the large numbers of people with undiagnosed celiac disease currently are seeking health care.

MeSH terms

  • Adolescent
  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Anemia / etiology
  • Celiac Disease / complications*
  • Celiac Disease / diagnosis*
  • Celiac Disease / pathology
  • Cost of Illness*
  • Diagnosis, Differential
  • Diarrhea / etiology*
  • Disease Progression
  • Female
  • Humans
  • Male
  • Middle Aged
  • Osteoporosis / etiology
  • Retrospective Studies