Function of the protein RPE65 in the visual cycle

Nutr Rev. 2005 Mar;63(3):97-100. doi: 10.1111/j.1753-4887.2005.tb00127.x.

Abstract

A protein called RPE65 performs a key role in the trans-cis isomerization of retinol in the retinal pigment epithelium of the eye. The palmitoylation of RPE65 serves to switch off the visual cycle in darkness and to switch it on in the light.

Publication types

  • Review

MeSH terms

  • Animals
  • Carrier Proteins
  • Eye Proteins / chemistry
  • Eye Proteins / metabolism
  • Eye Proteins / physiology*
  • Humans
  • Pigment Epithelium of Eye / metabolism
  • Pigment Epithelium of Eye / physiology*
  • Retina / metabolism
  • Retina / physiology*
  • Retinoid Isomerohydrolase
  • Vision, Ocular / physiology*
  • cis-trans-Isomerases

Substances

  • Carrier Proteins
  • Eye Proteins
  • cis-trans-Isomerases
  • Retinoid Isomerohydrolase