Regulation of mature T cell homeostasis

Semin Immunol. 2005 Jun;17(3):183-91. doi: 10.1016/j.smim.2005.02.007.


The overall size and the composition of the mature T cell pool are regulated by homeostatic mechanisms. Recent work has revealed that homeostatic signals are received from contact with two members of the common gamma chain family of cytokines, IL-7 and IL-15, and from self-MHC/peptide ligands. In essence, homeostasis of naïve T cells is regulated by IL-7 and self-MHC/peptide ligands and homeostasis of memory CD8 cells is controlled by IL-7 and IL-15. All of these signals also appear to be important to a varying degree for homeostasis of memory CD4 cells, but the details are less well understood than for other cell type.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cytokines / metabolism*
  • Gene Expression Regulation*
  • Homeostasis* / genetics
  • Humans
  • Immunologic Memory
  • Mice
  • T-Lymphocytes / immunology*
  • T-Lymphocytes / physiology


  • Cytokines