Neural integrator function in murine CACNA1A mutants

Ann N Y Acad Sci. 2005 Apr;1039:580-2. doi: 10.1196/annals.1325.072.

Abstract

Time constants of gaze holding are shortened in rocker and tottering mice, two strains whose cerebellar dysfunction stems from genetic alterations of the P/Q calcium channel. The finding suggests that in mice as in primates, the cerebellum contributes to the function of the neural integrator. Studying CACNA1A mutants may elucidate how cerebellar signals support gaze holding.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Calcium Channels, N-Type
  • Calcium Channels, P-Type / genetics*
  • Calcium Channels, Q-Type / genetics*
  • Cerebellar Ataxia / genetics
  • Cerebellum / physiology
  • Cerebellum / physiopathology
  • Fixation, Ocular
  • Mice
  • Mutation*
  • Primates
  • Signal Transduction

Substances

  • Calcium Channels, N-Type
  • Calcium Channels, P-Type
  • Calcium Channels, Q-Type
  • voltage-dependent calcium channel (P-Q type)