Whole grain consumption and risk of colorectal cancer: a population-based cohort of 60,000 women

Br J Cancer. 2005 May 9;92(9):1803-7. doi: 10.1038/sj.bjc.6602543.


We examined prospectively the association between whole grain consumption and colorectal cancer risk in the population-based Swedish Mammography Cohort. A total of 61,433 women completed a food-frequency questionnaire at baseline (1987-1990) and, through linkage with the Swedish Cancer Registry, 805 incident cases of colorectal cancer were identified during a mean follow-up of 14.8 years. High consumption of whole grains was associated with a lower risk of colon cancer, but not of rectal cancer. The multivariate rate ratio (RR) of colon cancer for the top category of whole grain consumption (> or = 4.5 servings day(-1)) compared with the bottom category (<1.5 servings day(-1)) was 0.67 (95% confidence interval (CI), 0.47-0.96; P-value for trend=0.06). The corresponding RR after excluding cases occurring within the first 2 years of follow-up was 0.65 (95% CI, 0.45-0.94; P-value for trend=0.04). Our findings suggest that high consumption of whole grains may decrease the risk of colon cancer in women.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Cohort Studies
  • Colonic Neoplasms / epidemiology
  • Colorectal Neoplasms / epidemiology*
  • Diet*
  • Dietary Fiber*
  • Female
  • Follow-Up Studies
  • Humans
  • Middle Aged
  • Prospective Studies
  • Rectal Neoplasms / epidemiology
  • Risk Factors
  • Secale*