Tuberculosis post-liver transplantation: a rare but complicated disease

Ann Acad Med Singap. 2005 Mar;34(2):213-5.

Abstract

Introduction: Tuberculosis is a rare but serious complication after transplantation. We report a case and discuss its presentation and management.

Clinical picture: A 60-year-old Indonesian male presented initially with fever, acute confusion and rapidly progressive right upper lobe pneumonia 3.5 months post-liver transplant, and was diagnosed with pulmonary tuberculosis by positive sputum smear for acid-fast bacilli and tuberculosis culture.

Treatment/outcome: Standard anti-tuberculosis therapy was administered but was complicated by interaction with cyclosporine and drug-induced cholestasis.

Conclusion: A high level of suspicion, prompt antituberculosis treatment and close follow-up are essential in management of post-transplant tuberculosis.

Publication types

  • Case Reports

MeSH terms

  • Antibiotics, Antitubercular / pharmacology
  • Cyclosporine / administration & dosage
  • Cyclosporine / blood
  • Drug Interactions
  • Humans
  • Immunocompromised Host
  • Immunosuppressive Agents / administration & dosage
  • Immunosuppressive Agents / blood
  • Liver Transplantation / adverse effects*
  • Male
  • Middle Aged
  • Rifampin / pharmacology
  • Tuberculosis, Pulmonary / drug therapy
  • Tuberculosis, Pulmonary / etiology*

Substances

  • Antibiotics, Antitubercular
  • Immunosuppressive Agents
  • Cyclosporine
  • Rifampin