The different outcomes of patients with disc herniation treated either by microdiscectomy, or by intradiscal ozone injection

Acta Neurochir Suppl. 2005:92:139-42. doi: 10.1007/3-211-27458-8_30.


Disc herniation with radiculopathy and chronic discogenic pain are the result of degenerative processes. Treatment approach in face of this problem has largely been debated in the last years. A number of reviews on surgical treatments in the '80s and '90s have been published and various new techniques have been introduced among which ozone discolysis is one non-invasive intradiscal treatment method. In a 3-year follow-up period we have investigated the different outcomes of 150 patients who received microdiscectomy and 150 patients who received intradiscal ozone injection. In this series results are in favour of discolysis for contained disc herniations and of microdiscectomy for large migrated fragments with pain so severe that open surgery was obligatory. Apart from this, our results with the two techniques are equivalent also concerning mild neurological motor deficits.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial

MeSH terms

  • Back Pain / diagnosis
  • Back Pain / epidemiology*
  • Back Pain / prevention & control*
  • Causality
  • Comorbidity
  • Diskectomy / statistics & numerical data*
  • Female
  • Humans
  • Injections, Spinal
  • Intervertebral Disc Chemolysis / statistics & numerical data*
  • Intervertebral Disc Displacement / diagnosis
  • Intervertebral Disc Displacement / epidemiology*
  • Intervertebral Disc Displacement / therapy*
  • Italy / epidemiology
  • Male
  • Microsurgery / statistics & numerical data
  • Ozone / administration & dosage*
  • Pain Measurement
  • Recovery of Function
  • Risk Assessment / methods
  • Risk Factors
  • Severity of Illness Index
  • Treatment Outcome


  • Ozone