The frontal lobes and the regulation of mental activity

Curr Opin Neurobiol. 2005 Apr;15(2):219-24. doi: 10.1016/j.conb.2005.03.006.


Results of neuroimaging and neuropsychological studies of frontal lobe function have been interpreted by some as evidence for specialized modules that are localized to distinct regions of frontal cortex, and that differ in both content and process from those in neighboring regions. These descriptions stand in stark contrast to the many domain-general theoretical accounts of the regulatory role of the frontal lobes in cognition. Recent attempts to understand how general regulatory mechanisms might operate across multiple domains (e.g. working memory, sentence comprehension) have been increasingly important in our understanding of the frontal lobes.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Cognition / physiology*
  • Frontal Lobe / physiology*
  • Humans
  • Learning / physiology*
  • Thinking / physiology*