Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 54 (5), 710-7

Epidemiology of Gastro-Oesophageal Reflux Disease: A Systematic Review

Affiliations
Review

Epidemiology of Gastro-Oesophageal Reflux Disease: A Systematic Review

J Dent et al. Gut.

Abstract

A systematic review of the epidemiology of gastro-oesophageal reflux disease (GORD) has been performed, applying strict criteria for quality of studies and the disease definition used. The prevalence and incidence of GORD was estimated from 15 studies which defined GORD as at least weekly heartburn and/or acid regurgitation and met criteria concerning sample size, response rate, and recall period. Data on factors associated with GORD were also evaluated. An approximate prevalence of 10-20% was identified for GORD, defined by at least weekly heartburn and/or acid regurgitation in the Western world while in Asia this was lower, at less than 5%. The incidence in the Western world was approximately 5 per 1000 person years. A number of potential risk factors (for example, an immediate family history and obesity) and comorbidities (for example, respiratory diseases and chest pain) associated with GORD were identified. Data reported in this systematic review can be interpreted with confidence as reflecting the epidemiology of "true" GORD. The disease is more common in the Western world than in Asia, and the low rate of incidence relative to prevalence reflects its chronicity. The small number of studies eligible for inclusion in this review highlights the need for global consensus on a symptom based definition of GORD.

Figures

Figure 1
Figure 1
Schema illustrating the need to distinguish between individuals who report minor reflux induced symptoms and those in whom these symptoms have significant impacts. The latter group makes up a minority of those who report reflux induced symptoms in population surveys.
Figure 2
Figure 2
Global variation in the prevalence of gastro-oesophageal reflux disease, defined as at least weekly heartburn and/or acid regurgitation.
Figure 3
Figure 3
Ethnic/regional differences in the prevalence of at least weekly heartburn alone, or at least weekly heartburn and/or acid regurgitation. Data are shown for population studies that satisfied criteria for inclusion in this review which evaluated specific ethnic groups. Data are from the studies indicated.
Figure 4
Figure 4
Factors associated with gastro-oesophageal reflux disease (GORD), suggesting their a priori likelihood of being influenced by the disease.
Figure 5
Figure 5
Data from a twin study which show evidence of a substantial contribution of genetic factors to occurrence of reflux disease, based on a high concordance for the presence of this problem in monozygotic compared with dizygotic twins.

Similar articles

  • Gastro-oesophageal Reflux Disease in Asia : Birth of a 'New' Disease?
    TK Cheung et al. Drugs 68 (4), 399-406. PMID 18318559. - Review
    Gastro-oesophageal reflux disease (GORD) is one of the most common gastrointestinal diseases in the Western world and imposes a heavy burden on society. Although its prev …
  • Update on the Epidemiology of Gastro-Oesophageal Reflux Disease: A Systematic Review
    HB El-Serag et al. Gut 63 (6), 871-80. PMID 23853213. - Review
    GERD is prevalent worldwide, and disease burden may be increasing. Prevalence estimates show considerable geographic variation, but only East Asia shows estimates consist …
  • Epidemiology of Reflux Symptoms and GORD
    J Ronkainen et al. Best Pract Res Clin Gastroenterol 27 (3), 325-37. PMID 23998972. - Review
    Gastro-oesophageal reflux disease (GORD) occurs when reflux of gastric contents causes troublesome symptoms and/or complications (the Montreal definition). GORD is a comm …
  • Epidemiology and Natural History of Gastro-Oesophageal Reflux Disease
    SJ Spechler. Digestion 51 Suppl 1, 24-9. PMID 1397743. - Review
    Epidemiological studies of gastro-oesophageal reflux disease (GORD) are confounded by the lack of a standardized definition and a diagnostic 'gold-standard' for the disor …
  • Gastro-oesophageal Reflux Disease in Asia
    KL Goh et al. J Gastroenterol Hepatol 15 (3), 230-8. PMID 10764021. - Review
    Gastro-oesophageal reflux disease (GORD) occurs more frequently in Europe and North America than in Asia but its prevalence is now increasing in many Asian countries. Man …
See all similar articles

Cited by 442 PubMed Central articles

See all "Cited by" articles
Feedback