New cytotoxic sulfated saponins from the starfish Certonardoa semiregularis

Arch Pharm Res. 2005 Mar;28(3):285-9. doi: 10.1007/BF02977793.

Abstract

Two new sulfated saponins designated as certonardosides P2 and I3 (1 and 2) were isolated from the brine shrimp active fraction of the MeOH extract of the starfish Certonardoa semiregularis. The structures were determined on the basis of spectral analysis. Compounds 1 and 2 were tested for cytotoxicity against five human tumor cell lines (A549, SK-OV-3, SK-MEL-2, XF498, and HCT15), and compound 1 displayed significant cytotoxicity against the SK-MEL-2 skin cancer cell.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / isolation & purification*
  • Antineoplastic Agents / pharmacology
  • Humans
  • Saponins / chemistry
  • Saponins / isolation & purification*
  • Saponins / pharmacology
  • Starfish / chemistry*
  • Sulfonic Acids / chemistry
  • Sulfonic Acids / isolation & purification*
  • Sulfonic Acids / pharmacology
  • Tumor Cells, Cultured

Substances

  • Antineoplastic Agents
  • Saponins
  • Sulfonic Acids
  • certonardoside P13
  • certonardoside P2