Severity of Guillain-Barré syndrome is associated with Fc gamma Receptor III polymorphisms

J Neuroimmunol. 2005 May;162(1-2):157-64. doi: 10.1016/j.jneuroim.2005.01.016.

Abstract

Macrophages and ganglioside-specific IgG are involved in the pathogenesis of Guillain-Barre syndrome (GBS). Leukocyte IgG receptors (Fc gammaR) confer potent cellular effector functions to the specificity of IgG. The efficacy of IgG-mediated cellular inflammatory responses is determined by functional polymorphisms of three Fc gammaR subclasses (Fc gammaRIIa: H131/R131; Fc gammaRIIIa: V158/F158; Fc gammaRIIIb: NA1/NA2). Fc gammaR genotype distributions were determined in a Dutch, and British cohort of GBS patients and controls. In addition, a meta-analysis incorporating all previously published data, encompassing a total of 345 GBS patients and 714 healthy controls, was performed. Results suggest that Fc gammaRIII genotypes may represent mild disease-modifying factors in GBS.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Cohort Studies
  • Female
  • Gene Frequency
  • Genetic Predisposition to Disease*
  • Genotype
  • Guillain-Barre Syndrome / genetics*
  • Guillain-Barre Syndrome / physiopathology
  • Humans
  • Male
  • Meta-Analysis as Topic
  • Middle Aged
  • Polymorphism, Genetic*
  • Receptors, Fc / classification
  • Receptors, Fc / genetics*
  • Retrospective Studies
  • Whites

Substances

  • Receptors, Fc