Retymicin, galtamycin B, saquayamycin Z and ribofuranosyllumichrome, novel secondary metabolites from Micromonospora sp. Tü 6368. I. Taxonomy, fermentation, isolation and biological activities
- PMID: 15835721
- DOI: 10.1038/ja.2005.12
Retymicin, galtamycin B, saquayamycin Z and ribofuranosyllumichrome, novel secondary metabolites from Micromonospora sp. Tü 6368. I. Taxonomy, fermentation, isolation and biological activities
Abstract
A new xanthone compound named retymicin (1) was isolated together with galtamycin B (2) and saquayamycin Z (3), new members of the galtamycin and saquayamycin families, respectively, and the new lumichrome derivative 1-(alpha-ribofuranosyl)-lumichrome (4) from Micromonospora strain Tü 6368, isolated from a soil sample collected in Romania. Retymicin, galtamycin B and saquayamycin Z show cytostatic effects to various human tumor cell lines whereas saquayamycin Z is also active against Gram-positive bacteria.
Similar articles
-
Retymicin, galtamycin B, saquayamycin Z and ribofuranosyllumichrome, novel secondary metabolites from Micromonospora sp. Tü 6368. II. Structure elucidation.J Antibiot (Tokyo). 2005 Feb;58(2):103-10. doi: 10.1038/ja.2005.13. J Antibiot (Tokyo). 2005. PMID: 15835722
-
[The antibiotic galtamycin. Its fermentation, isolation, physicochemical and biological properties].Antibiot Med Biotekhnol. 1986 Jun;31(6):428-31. Antibiot Med Biotekhnol. 1986. PMID: 3461745 Russian.
-
Cloning and sequencing of the biosynthetic gene cluster for saquayamycin Z and galtamycin B and the elucidation of the assembly of their saccharide chains.Chembiochem. 2009 May 25;10(8):1392-401. doi: 10.1002/cbic.200900054. Chembiochem. 2009. PMID: 19384899
-
Ripromycin and other polycyclic macrolactams from Streptomyces sp. Tü 6239: taxonomy, fermentation, isolation and biological properties.J Antibiot (Tokyo). 2003 Apr;56(4):364-71. doi: 10.7164/antibiotics.56.364. J Antibiot (Tokyo). 2003. PMID: 12817810
-
Arisostatins A and B, new members of tetrocarcin class of antibiotics from Micromonospora sp. TP-A0316. I. Taxonomy, fermentation, isolation and biological properties.J Antibiot (Tokyo). 2000 Mar;53(3):227-32. doi: 10.7164/antibiotics.53.227. J Antibiot (Tokyo). 2000. PMID: 10819292
Cited by
-
Selective isolation and rapid identification of members of the genus Micromonospora.Appl Environ Microbiol. 2008 Sep;74(17):5593-7. doi: 10.1128/AEM.00303-08. Epub 2008 Jul 11. Appl Environ Microbiol. 2008. PMID: 18621873 Free PMC article.
-
Automated, Multistep Continuous-Flow Synthesis of 2,6-Dideoxy and 3-Amino-2,3,6-trideoxy Monosaccharide Building Blocks.Angew Chem Int Ed Engl. 2021 Oct 18;60(43):23171-23175. doi: 10.1002/anie.202109887. Epub 2021 Sep 21. Angew Chem Int Ed Engl. 2021. PMID: 34463017 Free PMC article.
-
Modular continuous flow synthesis of orthogonally protected 6-deoxy glucose glycals.Org Biomol Chem. 2020 May 6;18(17):3254-3257. doi: 10.1039/d0ob00522c. Org Biomol Chem. 2020. PMID: 32293636 Free PMC article.
-
Tailoring enzymes involved in the biosynthesis of angucyclines contain latent context-dependent catalytic activities.Chem Biol. 2012 May 25;19(5):647-55. doi: 10.1016/j.chembiol.2012.04.010. Chem Biol. 2012. PMID: 22633416 Free PMC article.
-
Glycosyl Sulfonates Beyond Triflates.Chem Rec. 2021 Nov;21(11):3102-3111. doi: 10.1002/tcr.202100141. Epub 2021 Jun 17. Chem Rec. 2021. PMID: 34142755 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
