The Metabolic Syndrome

Lancet. 2005 Apr 16-22;365(9468):1415-28. doi: 10.1016/S0140-6736(05)66378-7.

Abstract

The metabolic syndrome is a common metabolic disorder that results from the increasing prevalence of obesity. The disorder is defined in various ways, but in the near future a new definition(s) will be applicable worldwide. The pathophysiology seems to be largely attributable to insulin resistance with excessive flux of fatty acids implicated. A proinflammatory state probably contributes to the syndrome. The increased risk for type 2 diabetes and cardiovascular disease demands therapeutic attention for those at high risk. The fundamental approach is weight reduction and increased physical activity; however, drug treatment could be appropriate for diabetes and cardiovascular disease risk reduction.

Publication types

  • Review

MeSH terms

  • Cardiovascular Diseases / etiology
  • Diabetes Mellitus / etiology
  • Humans
  • Insulin Resistance
  • Lipids / blood
  • Metabolic Syndrome* / complications
  • Metabolic Syndrome* / diagnosis
  • Metabolic Syndrome* / metabolism
  • Metabolic Syndrome* / therapy
  • Risk Factors

Substances

  • Lipids