NF-kappaB as a molecular target in adjuvant therapy of gastrointestinal carcinomas

Eur J Surg Oncol. 2005 May;31(4):386-92. doi: 10.1016/j.ejso.2004.10.010. Epub 2004 Dec 16.

Abstract

Aim: To describe the role of nuclear factor-kappa B (NF-kappaB) in cancer treatment.

Methods: We searched the Pubmed database (until Oct, 2004) with the keywords of gastrointestinal carcinoma, NF-kappaB, inhibitor, cancer treatment molecular target and chemoresistance. We reviewed the literature in the role of NF-kappaB activation in chemoresistance, tumour growth suppression and enhancement of apoptosis in gastrointestinal carcinomas.

Conclusions: Several possible strategies for inhibiting NF-kappaB activation are identified. The importance of targeting NF-kappaB as a potential therapeutic approach in clinical medicine was discussed.

Publication types

  • Review

MeSH terms

  • Antineoplastic Agents / pharmacology
  • Chemotherapy, Adjuvant
  • Gastrointestinal Neoplasms / drug therapy*
  • Gastrointestinal Neoplasms / metabolism*
  • Humans
  • NF-kappa B / antagonists & inhibitors*
  • NF-kappa B / physiology*

Substances

  • Antineoplastic Agents
  • NF-kappa B