Recent advances in the management of gout and hyperuricemia

Curr Opin Rheumatol. 2005 May;17(3):319-24. doi: 10.1097/01.bor.0000162060.25895.a5.


Purpose of review: To review the recent advances in the management of gout and hyperuricemia.

Recent findings: The first quality indicators for gout management have been proposed. Selective COX II inhibitors, as well as traditional NSAIDs, are effective in acute gout. A new xanthine oxidase inhibitor, febuxostat, and pegylated uricases are in clinical trials.

Summary: The therapeutic aims in gout include termination of the acute attack as promptly and gently as possible, prevention of future attacks, prevention or reversal of complications of the, and prevention or reversal of associated features such as obesity, hypertriglyceridemia, hypertension, or alcoholism.

Publication types

  • Review

MeSH terms

  • Gout / drug therapy*
  • Gout / metabolism
  • Humans
  • Hyperuricemia / drug therapy*
  • Hyperuricemia / metabolism
  • Treatment Outcome
  • Uric Acid / metabolism
  • Uricosuric Agents / therapeutic use*


  • Uricosuric Agents
  • Uric Acid