Cyclin E in normal and neoplastic cell cycles

Oncogene. 2005 Apr 18;24(17):2776-86. doi: 10.1038/sj.onc.1208613.


Cyclin E-Cdk2 has long been considered an essential and master regulator of progression through G1 phase of the cell cycle. Although recent mouse models have prompted a rethinking of cyclin E function in mammals, it remains clear that cyclin E impacts upon many processes central to cell division. Normal cells maintain strict control of cyclin E activity, and this is commonly disrupted in cancer cells. Moreover, cyclin E deregulation is thought to play a fundamental role in tumorigenesis. In this review, we discuss the regulation and functions of cyclin E in normal and neoplastic mammalian cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Cycle / physiology*
  • Cyclin E / metabolism
  • Cyclin E / physiology*
  • Cyclin-Dependent Kinases / metabolism
  • Humans
  • Mice
  • Mice, Knockout
  • Neoplasms / pathology*
  • Phosphorylation


  • Cyclin E
  • Cyclin-Dependent Kinases