Adenoma with gastric differentiation (so-called pyloric gland adenoma) in a heterotopic gastric corpus mucosa in the rectum

Virchows Arch. 2005 May;446(5):542-5. doi: 10.1007/s00428-005-1242-2. Epub 2005 Apr 19.


In a 46-year-old man, a pedunculated rectal polyp measuring 3.0x3.0x2.0 cm was diagnosed histologically as a pyloric gland-type adenoma arising in heterotopic gastric corpus mucosa. The luminal site was covered by glands of the gastric foveolar type, displaying focal marked proliferation interpreted as low-grade intraepithelial neoplasia. A bidirectional gastric differentiation was found: most lower glandular structures showed positivity for the deep gastric mucin core protein Muc 6 and superficial positivity for gastric foveolar epithelium mucin core protein Muc 5AC. Pyloric gland adenoma has so far been described in one larger series only and a few case reports of the stomach, gallbladder, pancreatic duct and within heterotopic gastric corpus mucosa of the duodenal bulb. The present case report is the first case of a pyloric gland-type adenoma within a gastric corpus heterotopia of the rectal mucosa.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenoma / pathology*
  • Cell Division
  • Choristoma*
  • Gastric Mucosa*
  • Humans
  • Intestinal Mucosa / pathology
  • Intestinal Polyps / chemistry
  • Intestinal Polyps / pathology*
  • Male
  • Middle Aged
  • Mucin 5AC
  • Mucin-6
  • Mucins / analysis
  • Rectal Neoplasms / chemistry
  • Rectal Neoplasms / pathology*
  • Stomach Neoplasms / chemistry
  • Stomach Neoplasms / pathology


  • MUC5AC protein, human
  • MUC6 protein, human
  • Mucin 5AC
  • Mucin-6
  • Mucins