Association of prothrombin gene mutation with sepsis in a preterm with multiple intracardiac thrombi

Echocardiography. 2005 Apr;22(4):340-4. doi: 10.1111/j.1540-8175.2005.03107.x.


We report for the first time, a premature infant with multiple intracardiac thrombi and sepsis, who was heterozygous for the G20210A prothrombin gene variant. Anticoagulant treatment with low molecular weight heparin resulted in the complete disappearance of the thrombi. It may be suggested that prothrombin gene variant associated with sepsis, respiratory distress syndrome, and perinatal asphyxia, as well as other thrombophilic disorders, could be a risk factor for the development of neonatal thrombus.

Publication types

  • Case Reports

MeSH terms

  • Disease Progression
  • Fatal Outcome
  • Gene Expression Regulation
  • Genetic Predisposition to Disease*
  • Heart Diseases / complications
  • Heart Diseases / diagnostic imaging
  • Heart Diseases / genetics*
  • Humans
  • Infant, Newborn
  • Infant, Premature*
  • Male
  • Mutation
  • Polymorphism, Genetic
  • Prothrombin / genetics*
  • Sepsis / complications
  • Sepsis / diagnosis*
  • Severity of Illness Index
  • Thromboembolism / complications
  • Thromboembolism / diagnostic imaging
  • Thromboembolism / genetics*
  • Ultrasonography


  • Prothrombin