A single bout of exercise at higher intensity enhances glucose effectiveness in sedentary men

J Clin Endocrinol Metab. 2005 Jul;90(7):4035-40. doi: 10.1210/jc.2004-2092. Epub 2005 Apr 19.


Objective: Previous studies have shown that glucose effectiveness and insulin sensitivity are acutely enhanced by exercise at various intensities. The aim of this study was to determine the effects of a single bout of exercise at intensities recommended by the American Diabetes Association (ADA) and the American College of Sports Medicine (ACSM) on glucose uptake-specific glucose effectiveness (S(G)(2)*) and insulin sensitivity (S(I)(2)*). S(G)(2)* and S(I)(2)* were estimated by a two-compartment minimal model.

Design: Six healthy men (age, 28.5 +/- 2.0 yr) performed a stable-labeled frequently sampled iv glucose tolerance test (FSIGT) under three separate conditions: without any prior exercise, and immediately after single 20-min bouts of cycle ergometer exercise at an intensity of 50% and 70% of maximal oxygen uptake (Vo(2max)). The exercise intensities were close to the lower and upper boundaries recommended by the ADA and ACSM.

Results: Glucose disappearance constant (K(G)), S(G)(2)*, and S(I)(2)* increased after exercise in an intensity-dependent manner. Increases in S(G)(2)* (+237.1 +/- 50.5%), S(I)(2)* (+225.6 +/- 51.9%), and K(G) (+151.7 +/- 16.5%) following exercise at 70% Vo(2max) were statistically significant (P < 0.05), whereas those at 50% Vo(2max) were not.

Conclusions: In conclusion, a single bout of exercise acutely improves S(I)(2)* and S(G)(2)* in individuals with normal glucose tolerance in an intensity-dependent manner.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • AMP-Activated Protein Kinases
  • Adult
  • Exercise*
  • Glucose / metabolism*
  • Glucose Tolerance Test
  • Glucose Transporter Type 4
  • Humans
  • Male
  • Monosaccharide Transport Proteins / metabolism
  • Multienzyme Complexes / metabolism
  • Muscle Proteins / metabolism
  • Protein-Serine-Threonine Kinases / metabolism


  • Glucose Transporter Type 4
  • Monosaccharide Transport Proteins
  • Multienzyme Complexes
  • Muscle Proteins
  • SLC2A4 protein, human
  • Protein-Serine-Threonine Kinases
  • AMP-Activated Protein Kinases
  • Glucose