Melanoma genetics and the development of rational therapeutics

J Clin Invest. 2005 Apr;115(4):813-24. doi: 10.1172/JCI24808.


Melanoma is a cancer of the neural crest-derived cells that provide pigmentation to skin and other tissues. Over the past 4 decades, the incidence of melanoma has increased more rapidly than that of any other malignancy in the United States. No current treatments substantially enhance patient survival once metastasis has occurred. This review focuses on recent insights into melanoma genetics and new therapeutic approaches being developed based on these advances.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Humans
  • Melanoma / genetics*
  • Melanoma / pathology
  • Melanoma / physiopathology
  • Melanoma / therapy*
  • Neoplasm Metastasis
  • Neoplasm Staging
  • Signal Transduction / genetics
  • Signal Transduction / physiology
  • Skin Neoplasms / genetics*
  • Skin Neoplasms / pathology
  • Skin Neoplasms / physiopathology
  • Skin Neoplasms / therapy*
  • ras Proteins / genetics
  • ras Proteins / metabolism


  • ras Proteins