Tissue plasminogen activator in central nervous system physiology and pathology

Thromb Haemost. 2005 Apr;93(4):655-60. doi: 10.1160/TH04-12-0838.


Although conventionally associated with fibrin clot degradation, recent work has uncovered new functions for the tissue plasminogen activator (tPA)/plasminogen cascade in central nervous system physiology and pathology. This extracellular proteolytic cascade has been shown to have roles in learning and memory, stress, neuronal degeneration, addiction and Alzheimer's disease. The current review considers the different ways tPA functions in the brain.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Brain / pathology*
  • Brain / physiology*
  • Gene Expression Regulation / physiology
  • Humans
  • Mice
  • Neurons / pathology
  • Neurons / physiology
  • Synapses / physiology
  • Tissue Plasminogen Activator / genetics
  • Tissue Plasminogen Activator / physiology*


  • Tissue Plasminogen Activator