Altered regional blood flow in the fetus: the origins of cardiovascular disease?

Acta Paediatr. 2004 Dec;93(12):1559-60.

Abstract

A fetal response to hypoxia and other adverse influences is to redistribute blood flow in order to "spare" the brain. This, however, is associated with reduced growth of the liver and kidneys.

Conclusion: The long-term consequences of fetal redistribution of blood flow are unknown, but preliminary evidence suggests that there is an increased risk of coronary heart disease and hypertension in later life.

Publication types

  • Comment

MeSH terms

  • Chronic Disease
  • Coronary Disease / etiology*
  • Coronary Disease / physiopathology*
  • Fetal Development / physiology*
  • Fetal Diseases / embryology
  • Fetal Diseases / physiopathology
  • Humans
  • Hypertension / etiology*
  • Hypertension / physiopathology*
  • Infant, Low Birth Weight
  • Infant, Newborn
  • Kidney / blood supply
  • Kidney / growth & development
  • Liver / blood supply
  • Liver / growth & development
  • Regional Blood Flow / physiology
  • Risk Factors
  • Time Factors