Magnesium-deficiency elevates circulating levels of inflammatory cytokines and endothelin

Mol Cell Biochem. 1992 Mar 25;110(2):169-73. doi: 10.1007/BF02454195.


We have developed two rodent models of diet-induced magnesium-deficiency in which histologically defined cardiac lesions can be induced within two to three weeks. During the development of these lesions, the magnesium-deficient animals exhibit circulating cytokine levels which are indicative of a generalized inflammatory state. Dramatic elevations of the macrophage-derived cytokines, IL-1, IL-6, and TNF-alpha together with significantly elevated levels of the endothelial cell-derived cytokine, endothelin, were detected in the plasma of these animals. We believe that the pathophysiological effects caused by the action of these cytokines may play a role in the promotion of cardiovascular pathology associated with magnesium deficiency.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cardiovascular Diseases / etiology
  • Cardiovascular Diseases / pathology
  • Cricetinae
  • Cytokines / blood*
  • Endothelins / blood*
  • Female
  • Magnesium Deficiency / blood*
  • Magnesium Deficiency / complications
  • Male
  • Mesocricetus
  • Rats
  • Rats, Inbred Strains


  • Cytokines
  • Endothelins