Comparison of in vitro activities of antifungal drugs and ethanolic extract of propolis against Trichophyton rubrum and T. mentagrophytes by using a microdilution assay

Mycoses. 2005 May;48(3):205-10. doi: 10.1111/j.1439-0507.2005.01128.x.


The in vitro activities of propolis against 29 strains of dermatophytes were compared with those of terbinafine, itraconazole, ketoconazole, and fluconazole. Minimal inhibitory concentrations (MICs) were determined according to a National Committee for Clinical Laboratory Standards broth microdilution method. Among the systemic antifungals tested, terbinafine was the most potent. Propolis showed important antifungal activity and it merits further investigation as a potentially useful agent for the treatment of dermatophytosis.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antifungal Agents / pharmacology*
  • Fluconazole / pharmacology
  • Itraconazole / pharmacology
  • Ketoconazole / pharmacology
  • Microbial Sensitivity Tests
  • Naphthalenes / pharmacology
  • Propolis / chemistry
  • Propolis / pharmacology*
  • Terbinafine
  • Trichophyton / drug effects*
  • Turkey


  • Antifungal Agents
  • Naphthalenes
  • Itraconazole
  • Fluconazole
  • Propolis
  • Terbinafine
  • Ketoconazole