Pruritic urticarial papules and plaques of pregnancy: current status

Australas J Dermatol. 2005 May;46(2):53-8; quiz 59. doi: 10.1111/j.1440-0960.2005.00160.x.


Pruritic urticarial papules and plaques of pregnancy is a common benign dermatosis of pregnancy that was described in 1979 as an intensely pruritic urticarial cutaneous eruption. This is a well-defined clinical entity that mainly occurs in primigravidas in the third trimester, which resolves spontaneously or with delivery and is usually responsive to topical treatments. The aetiology of PUPPP is obscure. Histology is non-specific, but consistently shows mild lymphohistiocytic perivascular inflammatory infiltrate with a variable number of eosinophils. Immunofluorescent studies are negative. The maternal and fetal prognosis are generally unaffected, and the condition is usually responsive to topical corticosteroids and oral antihistamines.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Administration, Cutaneous
  • Adrenal Cortex Hormones / administration & dosage
  • Female
  • Histamine H1 Antagonists / administration & dosage
  • Humans
  • Pregnancy
  • Pregnancy Complications / diagnosis*
  • Pregnancy Complications / drug therapy*
  • Pregnancy Complications / pathology
  • Pruritus / diagnosis*
  • Pruritus / drug therapy*
  • Pruritus / pathology


  • Adrenal Cortex Hormones
  • Histamine H1 Antagonists