Do statins increase the risk of idiopathic polyneuropathy?

Am J Cardiol. 2005 May 1;95(9):1097-9. doi: 10.1016/j.amjcard.2004.12.068.


A recent European case-control study suggested that statins increase the risk for polyneuropathy, a rare but serious neurologic condition. This risk was assessed in 272 patients with idiopathic polyneuropathy and 1,360 matched controls in the Intermountain Health Care electronic database. It was found that statin use before diagnosis was not significantly greater in patients than controls (odds ratio 1.30, 95% confidence interval 0.3 to 2.1, p = 0.27), nor were doses different between patients and controls.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Case-Control Studies
  • Databases, Factual
  • Delivery of Health Care, Integrated
  • Female
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / adverse effects*
  • Insurance Claim Review
  • Male
  • Middle Aged
  • Polyneuropathies / chemically induced*
  • Risk Assessment*
  • Risk Factors
  • Utah


  • Hydroxymethylglutaryl-CoA Reductase Inhibitors