Cited1 is a bifunctional transcriptional cofactor that regulates early nephronic patterning

J Am Soc Nephrol. 2005 Jun;16(6):1632-44. doi: 10.1681/ASN.2004060476. Epub 2005 Apr 20.

Abstract

In a screen to identify factors that regulate the conversion of mesenchyme to epithelium during the early stages of nephrogenesis, it was found that the Smad4-interacting transcriptional cofactor, Cited1, is expressed in the condensed cap mesenchyme surrounding the tip of the ureteric bud (UB), is downregulated after differentiation into epithelia, and has the capacity to block UB branching and epithelial morphogenesis in cultured metanephroi. Cited1 represses Wnt/beta-catenin but activates Smad4-dependent transcription involved in TGF-beta and Bmp signaling. By modifying these pathways, Cited1 may coordinate cellular differentiation and survival signals that regulate nephronic patterning in the metanephros.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cell Differentiation
  • Cell Survival
  • Cytoskeletal Proteins / physiology
  • DNA-Binding Proteins / physiology
  • Epithelium
  • Intercellular Signaling Peptides and Proteins / physiology
  • Kidney / embryology*
  • Kidney / physiology
  • Nuclear Proteins / physiology*
  • Organogenesis / physiology*
  • Rats
  • Signal Transduction
  • Smad4 Protein
  • Trans-Activators / physiology*
  • Transcription, Genetic
  • Transforming Growth Factor beta / physiology
  • Wnt Proteins
  • beta Catenin

Substances

  • Ctnnb1 protein, rat
  • Cytoskeletal Proteins
  • DNA-Binding Proteins
  • Intercellular Signaling Peptides and Proteins
  • Nuclear Proteins
  • Smad4 Protein
  • Smad4 protein, rat
  • Trans-Activators
  • Transforming Growth Factor beta
  • Wnt Proteins
  • beta Catenin