Use of long-acting tetracyclines for methicillin-resistant Staphylococcus aureus infections: case series and review of the literature

Clin Infect Dis. 2005 May 15;40(10):1429-34. doi: 10.1086/429628. Epub 2005 Apr 6.


Background: Few data exist on the efficacy of the long-acting tetracyclines doxycycline and minocycline against methicillin-resistant Staphylococcus aureus (MRSA) infection.

Methods: The medical records of 24 patients with serious tetracycline-susceptible MRSA infections who were treated with doxycycline or minocycline were reviewed. A review of the literature on the use of these antibiotics for treatment of both methicillin-susceptible and methicillin-resistant S. aureus infection was also performed.

Results: Complicated skin and skin-structure infections were most common (67%). Clinical cure was achieved in 20 (83%) of 24 patients in our case series. Both drugs were well-tolerated. The review of the literature on a total of 85 patients with S. aureus infection revealed similar results.

Conclusions: Long-acting tetracyclines may be a reasonable treatment alternative for patients with certain types of MRSA infection.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Anti-Bacterial Agents / administration & dosage
  • Anti-Bacterial Agents / therapeutic use*
  • Drug Therapy, Combination
  • Female
  • Humans
  • Male
  • Methicillin Resistance*
  • Middle Aged
  • Staphylococcal Infections / drug therapy*
  • Staphylococcal Infections / microbiology*
  • Staphylococcus aureus / drug effects*
  • Staphylococcus aureus / physiology
  • Tetracyclines / administration & dosage
  • Tetracyclines / therapeutic use*


  • Anti-Bacterial Agents
  • Tetracyclines