Abstract
We describe a newborn with multiple congenital anomalies consistent with an oro-facio-digital syndrome (OFDS). These are a group of inherited syndromes that have in common anomalies of the tongue (bifid or lobulated tongue with hamartomas), the face (median cleft lip) and the digits (brachydactyly, polydactyly, clinodactyly and/or syndactyly). OFDS has been classified into 11 types. The case described in this paper had manifestations overlapping with OFDS II (Mohr) and OFDS IV (Mohr-Majewski) and OFDS VI (Varadi). We propose that the present patient has a new variation of the OFDS due to the co-existence of the very atypical combination of polydactyly, cerebellar hypoplasia, hypothalamic hamartoma and classical facial findings of OFDS.
MeSH terms
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Brain Diseases / complications*
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Brain Diseases / genetics*
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Brain Diseases / pathology
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Cerebellum / abnormalities*
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Face / abnormalities*
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Foot Deformities, Congenital / complications
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Foot Deformities, Congenital / diagnostic imaging
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Genetic Variation / genetics*
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Hamartoma / complications*
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Hamartoma / genetics*
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Hamartoma / pathology
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Hand Deformities, Congenital / complications
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Hand Deformities, Congenital / diagnostic imaging
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Humans
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Hypothalamus* / pathology
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Infant, Newborn
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Magnetic Resonance Imaging
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Male
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Orofaciodigital Syndromes / complications*
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Orofaciodigital Syndromes / genetics*
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Orofaciodigital Syndromes / pathology
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Polydactyly / complications*
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Polydactyly / diagnosis
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Polydactyly / genetics*
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Tomography, X-Ray Computed