Hawthorn: potential roles in cardiovascular disease

Am J Chin Med. 2005;33(1):1-10. doi: 10.1142/S0192415X05002606.


Hawthorn (Crataegus) may play a role in the prevention and treatment of cardiovascular diseases such as hypertension, hyperlipidemia, and in particular, congestive heart failure. Evidence is accumulating that hawthorn may induce anti-ischemia/reperfusion-injury, anti-arrhythmic, hypolipidemic and hypotensive effects. These beneficial effects may in part be due to the presence of antioxidant flavonoid components. While a number of studies have been performed to evaluate the clinical efficacy of hawthorn, an international, multicenter, prospective clinical study including a large number of New York Heart Association (NYHA) class II/III heart failure patients is ongoing to test hawthorn's long-term therapeutic effects. Further clinical trials as well as pharmacokinetic and mechanistic studies are needed to explore and confirm its effectiveness, safety and pharmacological mechanism.

Publication types

  • Review

MeSH terms

  • Cardiovascular Diseases / drug therapy*
  • Crataegus*
  • Humans
  • Medicine, Chinese Traditional*
  • Phytotherapy*
  • Plant Preparations / therapeutic use*


  • Plant Preparations