Lucien J. Rubinstein: enduring contributions to neuro-oncology

Neurosurg Focus. 2005 Apr 15;18(4):e8. doi: 10.3171/foc.2005.18.4.9.


Dr. Lucien Rubinstein is best remembered for his significant contributions to the field of neuropathology, particularly in the classification of nervous system tumors. His accomplishments in basic neuro-oncology and in the formulation of diagnostic principles reflected a unique talent for synthesizing fundamental clinicopathological concepts based on skillful diagnostic investigation and a thorough understanding of neurobiology. Dr. Rubinstein was the leader in the establishment of cell cultures from central nervous system (CNS) tumors. He meticulously analyzed both light and electron microscopic features of CNS tumors, recorded his findings, and patiently drew sketches to be shared generously with his colleagues and students. As a pioneer in neuropathology, in his work Dr. Rubinstein set the foundation for many enduring concepts in neurosurgery, neuro-oncology, neurology, and basic tumor biology.

Publication types

  • Biography
  • Historical Article
  • Portrait
  • Review

MeSH terms

  • Biomarkers, Tumor / analysis
  • Biomarkers, Tumor / history
  • Brain Neoplasms / diagnosis*
  • Brain Neoplasms / history*
  • Brain Neoplasms / physiopathology
  • Diagnosis, Differential
  • History, 20th Century
  • Humans
  • Neurology / history*
  • Neurosurgery / history
  • Pathology / history*
  • Pathology, Clinical / history
  • Tumor Cells, Cultured / pathology


  • Biomarkers, Tumor

Personal name as subject

  • Lucien Rubenstein