Facile and convenient syntheses of 6,11-dihydro-5H-indeno[1,2-c]isoquinolin- 5-ones and 6,11-dihydro-5H-indolo[3,2-c]isoquinolin-5-one

Prakash G Jagtap; Erkan Baloglu; Garry Southan; William Williams; Aloka Roy; Alexander Nivorozhkin; Nelson Landrau; Kevin Desisto; Andrew L Salzman; Csaba Szabó

doi:10.1021/ol050331m

Facile and convenient syntheses of 6,11-dihydro-5H-indeno[1,2-c]isoquinolin- 5-ones and 6,11-dihydro-5H-indolo[3,2-c]isoquinolin-5-one

Org Lett. 2005 Apr 28;7(9):1753-6. doi: 10.1021/ol050331m.

Authors

Prakash G Jagtap¹, Erkan Baloglu, Garry Southan, William Williams, Aloka Roy, Alexander Nivorozhkin, Nelson Landrau, Kevin Desisto, Andrew L Salzman, Csaba Szabó

Affiliation

¹ Inotek Pharmaceuticals Corporation, 100 Cummings Center, Beverly, Massachusetts 01915, USA. pjagtap@inotekcorp.com

PMID: 15844898
DOI: 10.1021/ol050331m

Abstract

[reaction: see text] The synthesis of 6,11-dihydro-5H-indeno[1,2-c]isoquinolin-5-ones from the base-promoted condensation reaction of homophthalic anhydride and 2-(bromomethyl)-benzonitrile and a convenient method for the synthesis of indolo[3,2-c]isoquinolinones are described.

Publication types

Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Combinatorial Chemistry Techniques*
Indenes / chemical synthesis*
Indoles / chemical synthesis*
Isoquinolines / chemical synthesis*
Stereoisomerism

Substances

Indenes
Indoles
Isoquinolines

Abstract

Publication types

MeSH terms

Substances

Grants and funding