Anti-babesial and anti-plasmodial compounds from Phyllanthus niruri

J Nat Prod. 2005 Apr;68(4):537-9. doi: 10.1021/np0497245.

Abstract

Bioassay-guided fractionation of boiled aqueous extracts from the whole plant of Phyllanthus niruri led to the isolation of 1-O-galloyl-6-O-luteoyl-alpha-d-glucose (1), with IC(50) values of 4.7 microg/mL against Babesia gibsoni and 1.4 microg/mL against Plasmodium falciparum in vitro. The known compounds beta-glucogallin (2), quercetin 3-O-beta-d-glucopyranosyl-(2-->1)-O-beta-d-xylopyranoside (3), beta-sitosterol, and gallic acid were also isolated. Structures of these compounds were elucidated on the basis of their chemical and spectroscopic data.

MeSH terms

  • Animals
  • Babesia / drug effects*
  • Gallic Acid / analogs & derivatives*
  • Gallic Acid / chemistry
  • Gallic Acid / isolation & purification*
  • Gallic Acid / pharmacology
  • Gas Chromatography-Mass Spectrometry
  • Glucose / analogs & derivatives*
  • Glucose / chemistry
  • Glucose / isolation & purification*
  • Glucose / pharmacology
  • Glucosides / chemistry
  • Glucosides / isolation & purification*
  • Glucosides / pharmacology
  • Indonesia
  • Inhibitory Concentration 50
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Phyllanthus / chemistry*
  • Plants, Medicinal / chemistry*
  • Plasmodium falciparum / drug effects*

Substances

  • 1-O-galloyl-6-O-luteoyl-alpha-D-glucose
  • Glucosides
  • Gallic Acid
  • Glucose