Cremastrine, a pyrrolizidine alkaloid from Cremastra appendiculata

Yoshitaka Ikeda; Hikaru Nonaka; Tamotsu Furumai; Yasuhiro Igarashi

doi:10.1021/np049650x

Cremastrine, a pyrrolizidine alkaloid from Cremastra appendiculata

J Nat Prod. 2005 Apr;68(4):572-3. doi: 10.1021/np049650x.

Authors

Yoshitaka Ikeda¹, Hikaru Nonaka, Tamotsu Furumai, Yasuhiro Igarashi

Affiliation

¹ Pharmaceuticals Research Unit, Mitsubishi Pharma Corporation, 2-25-1, Shodai-Ohtani, Hirakata, Osaka 573-1153, Japan. Ikeda.Yoshitaka@mc.m-pharma.co.jp

PMID: 15844951
DOI: 10.1021/np049650x

Abstract

A new pyrrolizidine alkaloid, cremastrine (1), was isolated from the bulbs of Cremastra appendiculata. Its configuration was determined by spectroscopic and chemical analyses. Compound 1 inhibited the binding of tritium-labeled N-methylscopolamine to the muscarinic M3 receptor with a K(i) value of 126 nM.

MeSH terms

Japan
Molecular Structure
N-Methylscopolamine / pharmacology
Nuclear Magnetic Resonance, Biomolecular
Orchidaceae / chemistry*
Plants, Medicinal / chemistry*
Pyrrolizidine Alkaloids* / chemistry
Pyrrolizidine Alkaloids* / isolation & purification
Pyrrolizidine Alkaloids* / pharmacokinetics
Pyrrolizidine Alkaloids* / pharmacology
Receptor, Muscarinic M3 / metabolism*

Substances

Pyrrolizidine Alkaloids
Receptor, Muscarinic M3
cremastrine
N-Methylscopolamine