Cremastrine, a pyrrolizidine alkaloid from Cremastra appendiculata

J Nat Prod. 2005 Apr;68(4):572-3. doi: 10.1021/np049650x.

Abstract

A new pyrrolizidine alkaloid, cremastrine (1), was isolated from the bulbs of Cremastra appendiculata. Its configuration was determined by spectroscopic and chemical analyses. Compound 1 inhibited the binding of tritium-labeled N-methylscopolamine to the muscarinic M3 receptor with a K(i) value of 126 nM.

MeSH terms

  • Japan
  • Molecular Structure
  • N-Methylscopolamine / pharmacology
  • Nuclear Magnetic Resonance, Biomolecular
  • Orchidaceae / chemistry*
  • Plants, Medicinal / chemistry*
  • Pyrrolizidine Alkaloids* / chemistry
  • Pyrrolizidine Alkaloids* / isolation & purification
  • Pyrrolizidine Alkaloids* / pharmacokinetics
  • Pyrrolizidine Alkaloids* / pharmacology
  • Receptor, Muscarinic M3 / metabolism*

Substances

  • Pyrrolizidine Alkaloids
  • Receptor, Muscarinic M3
  • cremastrine
  • N-Methylscopolamine