Interleukin-15 enhances innate and adaptive immune responses to blood-stage malaria infection in mice

Infect Immun. 2005 May;73(5):3172-7. doi: 10.1128/IAI.73.5.3172-3177.2005.

Abstract

Compared to C57BL/6 wild-type mice, interleukin-15(-/-) (IL-15(-/-)) mice showed delayed clearance of Plasmodium chabaudi AS infection, lower type 1 cytokine production, impaired dendritic cell and NK cell functions, and lower titers of malaria-specific antibodies. Thus, IL-15 supports early control and timely resolution of blood-stage malaria through promotion of Th1-dependent innate and adaptive immune responses.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies, Protozoan / blood
  • Cytokines / blood
  • Dendritic Cells / immunology
  • Immunity, Innate
  • Interleukin-15 / genetics
  • Interleukin-15 / immunology*
  • Killer Cells, Natural / immunology
  • Malaria / immunology*
  • Malaria / mortality
  • Malaria / parasitology
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Parasitemia / immunology*
  • Parasitemia / mortality
  • Parasitemia / parasitology
  • Plasmodium chabaudi / immunology
  • Plasmodium chabaudi / pathogenicity*
  • Th1 Cells / immunology

Substances

  • Antibodies, Protozoan
  • Cytokines
  • Interleukin-15