Drug resistance and antiretroviral drug development

J Antimicrob Chemother. 2005 Jun;55(6):817-20. doi: 10.1093/jac/dki127. Epub 2005 Apr 21.


As more drugs for treating HIV have become available, drug resistance profiles within antiretroviral drug classes have become increasingly important for researchers developing new drugs and for clinicians integrating new drugs into their clinical practice. In vitro passage experiments and comprehensive phenotypic susceptibility testing are used for the pre-clinical evaluation of drug resistance. Clinical studies are required, however, to delineate the full spectrum of mutations responsible for resistance to a new drug and to identify the settings in which a new drug is likely to be most useful for salvage therapy.

Publication types

  • Review

MeSH terms

  • Anti-HIV Agents / pharmacology*
  • Drug Design*
  • Drug Resistance, Viral*
  • Drug Therapy, Combination
  • Genotype
  • Humans
  • Phenotype


  • Anti-HIV Agents