An electrolyte-based solution that increases corneal glycogen and conjunctival goblet-cell density in a rabbit model for keratoconjunctivitis sicca

Ophthalmology. 1992 Apr;99(4):600-4. doi: 10.1016/s0161-6420(92)31929-3.


Thirty-two rabbits with monocular surgically induced keratoconjunctivitis sicca (KCS) underwent masked treatment for 12 weeks with 1 of 4 artificial tear solutions. Disease in each group of treated rabbits was compared with disease in untreated KCS controls. One of the solutions tested was a unique electrolyte-based formulation shown previously to preserve normal goblet-cell density after extended exposure in normal rabbits. Only the electrolyte-based solution decreased elevated tear osmolarity and sodium after 9 weeks of treatment (P less than 0.05). At 20 weeks, mean corneal glycogen and conjunctival goblet-cell density in eyes treated with the electrolyte-based solution increased significantly relative to untreated KCS controls (P less than 0.01). With the other three solutions, mean glycogen levels and goblet-cell densities were either decreased relative to untreated KCS controls (P less than 0.05) or were unchanged. The electrolyte-based solution is the first treatment to increase corneal glycogen and conjunctival goblet cells in a rabbit model of KCS.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cell Count / drug effects
  • Conjunctiva / cytology*
  • Cornea / metabolism*
  • Disease Models, Animal
  • Electrolytes
  • Female
  • Glycogen / metabolism*
  • Hypotonic Solutions / therapeutic use*
  • Keratoconjunctivitis Sicca / drug therapy*
  • Keratoconjunctivitis Sicca / metabolism
  • Keratoconjunctivitis Sicca / pathology
  • Male
  • Ophthalmic Solutions / therapeutic use*
  • Osmolar Concentration
  • Rabbits
  • Random Allocation
  • Tears / metabolism


  • Electrolytes
  • Hypotonic Solutions
  • Ophthalmic Solutions
  • Glycogen