Brain arteriovenous malformations in adults

Lancet Neurol. 2005 May;4(5):299-308. doi: 10.1016/S1474-4422(05)70073-9.


Arteriovenous malformations of the brain (AMB) can cause stroke when they rupture. Epidemiological and imaging research has found that about 50% of patients with AMB present with haemorrhage, and the other 50% either present with non-focal symptoms, such as headache, seizure, or focal neurological deficit, or have no symptoms and the lesion is found during unrelated investigations. Treatment for arteriovenous malformations aims to prevent and resolve haemorrhage and is a growing interdisciplinary challenge. Although treatment uses enormous resources, there have been few studies on the risk-benefit ratios for treatment of unruptured AMB and the best approaches.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Adult
  • Cerebral Arteries / abnormalities
  • Cerebral Arteries / pathology
  • Cerebral Arteries / physiopathology
  • Cerebral Hemorrhage / mortality*
  • Cerebral Hemorrhage / prevention & control*
  • Cerebral Hemorrhage / therapy
  • Cerebral Veins / abnormalities
  • Cerebral Veins / pathology
  • Cerebral Veins / physiopathology
  • Embolization, Therapeutic / methods
  • Embolization, Therapeutic / statistics & numerical data
  • Embolization, Therapeutic / trends
  • Follow-Up Studies
  • Humans
  • Interdisciplinary Communication
  • Intracranial Arteriovenous Malformations / mortality*
  • Intracranial Arteriovenous Malformations / physiopathology*
  • Intracranial Arteriovenous Malformations / therapy
  • Risk Assessment
  • Treatment Outcome