Correlation dimension analysis of heart rate variability in patients with dilated cardiomyopathy

Comput Methods Programs Biomed. 2005 May;78(2):133-40. doi: 10.1016/j.cmpb.2005.01.004.

Abstract

A correlation dimension analysis of heart rate variability (HRV) was applied to a group of 55 patients with dilated cardiomyopathy (DCM) and 55 healthy subjects as controls. The 24-h RR time series for each subject was divided into segments of 10,000 beats to determine the correlation dimension (CD) per segment. A study of the influence of the time delay (lag) in the calculation of CD was performed. Good discrimination between both groups (p<0.005) was obtained with lag values of 5 or greater. CD values of DCM patients (8.4+/-1.9) were significantly lower than CD values for controls (9.5+/-1.9). An analysis of CD values of HRV showed that for healthy people, CD night values (10.6+/-1.8) were significant greater than CD day values (9.2+/-1.9), revealing a circadian rhythm. In DCM patients, this circadian rhythm was lost and there were no differences between CD values in day (8.8+/-2.4) and night (8.9+/-2.1).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Algorithms
  • Cardiomyopathy, Dilated* / physiopathology
  • Case-Control Studies
  • Circadian Rhythm
  • Female
  • Germany
  • Heart Rate*
  • Humans
  • Male
  • Middle Aged
  • Statistics as Topic / methods*