Brief exposure to high magnetic fields determines microtubule self-organisation by reaction-diffusion processes

Biophys Chem. 2005 May 1;115(1):29-35. doi: 10.1016/j.bpc.2004.12.048. Epub 2005 Jan 19.

Abstract

A frequent feature of microtubule organisation in living systems is that it can be triggered by a variety of biochemical or physical factors. Under appropriate conditions, in vitro microtubule preparations self-organise by a reaction-diffusion process in which self-organisation depends upon, and can be triggered by, weak external physical factors such as gravity. Here, we show that self-organisation is also strongly dependent upon the presence of a high magnetic field, for a brief critical period early in the process, and before any self-organised pattern is visible. These results provide evidence that external physical factors trigger self-organisation by way of an orientational bias that breaks the symmetry of the reaction-diffusion process. As microtubule organisation is central to many cell functions, this behaviour provides a mechanism by which strong magnetic fields can intervene in biological processes.

MeSH terms

  • Animals
  • Cattle
  • Diffusion
  • Electromagnetic Fields*
  • Microtubules / chemistry*
  • Microtubules / radiation effects*
  • Microtubules / ultrastructure
  • Tubulin / chemistry*
  • Tubulin / radiation effects*

Substances

  • Tubulin