Clinical efficacy of apple polyphenol for treating cedar pollinosis

Biosci Biotechnol Biochem. 2005 Apr;69(4):829-32. doi: 10.1271/bbb.69.829.


A double-blind comparative study was conducted on cedar pollinosis patients in order to evaluate the treatment efficacy of apple polyphenol (Ap). Ap was administered (500 mg) once daily for 12 weeks, starting about 2 weeks prior to cedar pollen dispersion. Pollinosis symptoms during the study were evaluated according to the classification in the guidelines for allergic rhinitis diagnosis and treatment. The results show that the sneezing score was significantly lower for the Ap group than with the placebo group during the early period of pollen dispersion and during the main dispersion period. In addition, no adverse reactions were induced by Ap during the study. These results suggest that Ap may alleviate the symptoms of cedar pollinosis.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Anti-Allergic Agents / administration & dosage
  • Anti-Allergic Agents / adverse effects
  • Anti-Allergic Agents / therapeutic use*
  • Cedrus / immunology*
  • Double-Blind Method
  • Flavonoids / administration & dosage
  • Flavonoids / adverse effects
  • Flavonoids / therapeutic use*
  • Humans
  • Japan
  • Malus / chemistry*
  • Phenols / administration & dosage
  • Phenols / adverse effects
  • Phenols / therapeutic use*
  • Pollen / immunology*
  • Polyphenols
  • Rhinitis, Allergic, Perennial / complications
  • Rhinitis, Allergic, Perennial / drug therapy*
  • Rhinitis, Allergic, Perennial / physiopathology
  • Sneezing
  • Time Factors


  • Anti-Allergic Agents
  • Flavonoids
  • Phenols
  • Polyphenols