RBM15-MKL1 (OTT-MAL) fusion transcript in an adult acute myeloid leukemia patient

Am J Hematol. 2005 May;79(1):43-5. doi: 10.1002/ajh.20298.

Abstract

The t(1;22)(p13;q13) is a nonrandom chromosomal abnormality in acute leukemia with the fusion oncogene, RBM15-MKL1 (OTT-MAL), identified recently. However, this abnormality has been described only in infants and young children with acute megakaryoblastic leukemia (AMKL). We report a 59-year-old male patient with the diagnosis of acute myeloid leukemia, subtype M1, who harbors an abnormal chromosome +der(1)t(1;22)(p13;q13). The RBM15-MKL1 (OTT-MAL) fusion transcript was also confirmed by the reverse transcriptase-polymerase chain reaction. This unusual abnormality is rare in adult cases of leukemia, and in children it is restricted to AMKL. This report is accompanied by a review of the literature on the t(1;22)(p13;q13).

Publication types

  • Case Reports

MeSH terms

  • Acute Disease
  • Adult
  • Base Sequence
  • Chromosomes, Human, Pair 1*
  • Chromosomes, Human, Pair 5*
  • DNA Primers
  • DNA-Binding Proteins / genetics*
  • Humans
  • Leukemia, Myeloid / genetics*
  • Male
  • Oncogene Proteins, Fusion / genetics*
  • RNA-Binding Proteins / genetics*
  • Reverse Transcriptase Polymerase Chain Reaction
  • Trans-Activators
  • Translocation, Genetic*

Substances

  • DNA Primers
  • DNA-Binding Proteins
  • MRTFA protein, human
  • Oncogene Proteins, Fusion
  • RBM15 protein, human
  • RNA-Binding Proteins
  • Trans-Activators