[Optic neuritis associated with infliximab]

J Fr Ophtalmol. 2005 Feb;28(2):201-4. doi: 10.1016/s0181-5512(05)81044-7.
[Article in French]


Infliximab is a chimeric human-murine monoclonal antibody of the IgG1 type with a high affinity and specificity for tumor necrosis factor alpha (TNFalpha). Infliximab was used in Crohn disease, rheumatoid arthritis, spondyloarthropathy, juvenile idiopathic arthritis, Behcet's disease, Wegener's granulomatosis, HLA-B27-associated uveitis and chronic severe refractory uveitis. Reported adverse effects of this treatment were infections, development of antinuclear antibodies and anti double-stranded DNA, lymphomas, and exacerbation of demyelinating disease. We report a case of infliximab-associated optic neuritis with favorable outcome after systemic steroid treatment.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Antibodies, Monoclonal / adverse effects*
  • Antirheumatic Agents / adverse effects*
  • Female
  • Humans
  • Infliximab
  • Middle Aged
  • Optic Neuritis / chemically induced*


  • Antibodies, Monoclonal
  • Antirheumatic Agents
  • Infliximab