MicroRNA Biogenesis: Coordinated Cropping and Dicing

Nat Rev Mol Cell Biol. 2005 May;6(5):376-85. doi: 10.1038/nrm1644.

Abstract

The recent discovery of microRNAs (miRNAs) took many by surprise because of their unorthodox features and widespread functions. These tiny, approximately 22-nucleotide, RNAs control several pathways including developmental timing, haematopoiesis, organogenesis, apoptosis, cell proliferation and possibly even tumorigenesis. Among the most pressing questions regarding this unusual class of regulatory miRNA-encoding genes is how miRNAs are produced in cells and how the genes themselves are controlled by various regulatory networks.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Gene Expression Regulation
  • MicroRNAs / biosynthesis*
  • MicroRNAs / genetics*
  • MicroRNAs / metabolism
  • Plants / genetics
  • Plants / metabolism
  • Transcription, Genetic

Substances

  • MicroRNAs