Moving messages: the intracellular localization of mRNAs

Nat Rev Mol Cell Biol. 2005 May;6(5):363-75. doi: 10.1038/nrm1643.


mRNA localization is a common mechanism for targeting proteins to regions of the cell where they are required. It has an essential role in localizing cytoplasmic determinants, controlling the direction of protein secretion and allowing the local control of protein synthesis in neurons. New methods for in vivo labelling have revealed that several mRNAs are transported by motor proteins, but how most mRNAs are coupled to these proteins remains obscure.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Active Transport, Cell Nucleus / physiology
  • Animals
  • Cytoplasm / chemistry
  • Cytoplasm / metabolism
  • Microtubules / chemistry
  • Microtubules / metabolism
  • Myosins / metabolism
  • Protein Biosynthesis*
  • RNA, Messenger / analysis*
  • RNA, Messenger / metabolism*
  • RNA-Binding Proteins / genetics
  • RNA-Binding Proteins / metabolism


  • RNA, Messenger
  • RNA-Binding Proteins
  • Myosins